Antibiotics are mainly a class of secondary metabolites produced by microorganisms in the course of their productive life. They are one of the great achievements of mankind in the field of medicine and have played a very important role in the improvement of human health and safety of life.
CD BioSciences provides an advanced technology platform for antibiotics screening service, hoping to discovery novel antibiotics. The unique MicroScanTM technology platform is development to meet customer's personalized customization needs.
Overview of Antibiotics
Antibiotics have chemical substances that are resistant to pathogens or interfere with the developmental functions of other living cells. The first antibiotic was penicillin, discovered by Alexander Fleming in 1928.
- Limitations of Antibiotics
Extensive use of antibiotics can easily lead to bacterial resistance. The continuous evolution of drug-resistant strains poses a serious threat to public health. Therefore, there is an urgent need to promote the development of new antibiotics and the improvement of existing antibiotics while preventing the abuse of antibiotics. - Methods for Antibiotic Screening
- Microbiological Assays
The most classic method of antibiotic detection is the microbial assay. Screening using wild-type bacteria can include all antimicrobial targets and has a more comprehensive assay. In conclusion, microbiological testing usually requires a large amount of equipment and sterile laboratory facilities, making it difficult to adopt widely. - Physical and Chemical Assays
Specific properties of antibiotic molecules are analyzed using physical and chemical methods. Such as size, charge, binding properties, or reaction properties, can identify antibiotics in different samples. However, this method does not allow direct observation of the bioactive effect of antibiotics. - Immunoassays
Relying on the interaction between antibodies and specific molecules, highly sensitive and specific detection of antibiotics in complex liquid or treated solid samples is possible. However, antibodies may react with non-biologically active components of the antibiotic degradation pathway, thereby reducing the specificity of the test. - Sensitive-resistant Pair Screening
Screening using drug-sensitive and single-resistant (mutations with specific markers) organisms is another way to discover new antibiotics. By comparing controls, it is possible to determine whether a specific antibiotic is present in a given sample.
Our Service
CD BioSciences provides antibiotics screening service. Based on Human-associated Bacteria Screening Service, the company has strain resources and prebiotic categories for customers to choose from. The unique MicroScanTM technology platform allows simultaneous detection of the activity of the sample to be tested against multiple strains of bacteria. This platform offers a new approach to antibiotic screening that can be applied to the detection of any unknown substance.
- Multi-phenotypes Screening
By analyzing multiple phenotypes of indicator bacteria on the same batch of experiments, we can provide short, comprehensive screening experiments for antibiotic screening. - High-throughput Prebiotic Screening
We can screen thousands of compounds on the same batch of experiments.
Features of Our Services
Unique Customization
Based on the screening requirements, the perform conditions design.
Fast Delivery
You are guaranteed to submit your results within your expected time.
Comprehensive Service
Professional pre-sales, in-sales and after-sales service to answer your questions in detail.
CD BioSciences is committed to providing professional and efficient service to our customers around the world. As a pioneer in biotechnology, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. If you would like more information, please contact us.
References
- Singh, S. B. et al. (2011). "Screening strategies for discovery of antibacterial natural products." Expert Rev Anti Infect Ther. 9 (8): 589-613.
- Parthasarathy, R. et al. (2018). "Methods for field measurement of antibiotic concentrations: limitations and outlook." FEMS Microbiol Ecol. 94 (8).