Quorum sensing is a physiological behavior of bacteria that is genetically regulated in response to changes in cell density. It has broad application prospects in agriculture, medicine, environmental protection and other fields.
CD BioSciences offers quorum sensing analysis to help customers explore the conditions under which quorum sensing occurs and how quorum sensing signals coordinate bacterial community behavior. Our MicroScanTM technology platform is development to meet customer's personalized customization needs.
Overview of Quorum Sensing
When the bacterial population increases to a certain level, bacteria secrete and recognize through signaling molecules, which regulate population behavior such as gene level transfers, virulence factor secretion, budding spore production and biofilm formation. Bacteria with quorum sensing produce a signaling molecule known as auto inducer. According to the different targets of signaling molecules, they are classified into the followings.
- Acyl-homoserine Lactones (AHLs)
Acyl homoserine lactones (AHL) are important signaling molecules in the regulation of quorum-sensing genes discovered in Gram-negative bacteria. AHLs are produced by acyl-homoserine lactone synthase. - Autoinducing Peptides (AIPs)
In Gram-positive bacteria, quorum sensing is often controlled by small secreted peptides called auto-inducible peptides (AIPs). AIPs is synthesized from the ribosome as a precursor peptide. - Autoinducer 2 (AI-2)
It is generally accepted that AI-2 is an important quorum-sensing signaling molecule in both Gram-positive and Gram-negative bacteria. The signaling activity is limited to bacteria with specific AI-2 receptors.
Applications of Quorum Sensing
- Biosynthesis
Dynamic regulation of colony behavior is a new approach to balancing cell growth and chemical production. quorum sensing is a natural sensing system that researchers have used in biological circuits. By dynamically monitoring the population status and density, the production of metabolites is made more efficient. - Pathogenic Bacteria Control
The quorum sensing system plays a key regulatory role in the regulation of pathogen virulence and resistance. By inhibiting the relevant pathway quorum -sensing signaling factors, virulence factor synthesis as well as biofilm formation can be inhibited. Thus, pathogenic bacteria can be prevented from producing pathogenic effects, and the effectiveness of antibiotics can also be improved. - Biological Pollution Treatment
Quorum sensing is involved in biofilm formation. By interfering and blocking the QS pathway of bacteria, the biofilm formation can be reduced or inhibited. It provides new ideas for membrane biofouling control and development of anti-pollution membrane materials in water treatment applications. - Infectious Diseases Treatment
The virulence of pathogenic bacteria is regulated by the quorum sensing system. Therefore, targeting quorum sensing and regulating key steps in the quorum sensing process can be used to treat infectious diseases. It can provide new ideas for antibiotic design.
Our Service
Quorum sensing is an important mechanism for signaling and communication among bacteria. CD BioSciences provides quorum sensing analysis services, which is based on the MicroScanTM technology platform. This technology platform can help customers explore the conditions under which quorum sensing occurs and how quorum sensing signals coordinate bacterial. This advanced platform provides a new approach to quorum sensing analysis of microorganisms that can be applied to any microbial population.
- Providing a Variety of Quorum Sensing Signaling Molecules
- Suitable for Single or Combined Bacteria Discovery
The platform is suitable for quorum sensing studies of one or more bacteria.
Features of Our Services
Accelerating Innovation
The platform will accelerate innovative research in quorum sensing.
Fast Delivery
In the help of a professional team, can get your results within your expectations.
Comprehensive Service
To free you from hassles, we offer a one-stop service.
CD BioSciences is committed to providing professional and efficient service to our customers around the world. With high-quality reagents and comprehensive services, CD BioSciences has grown into one of the largest independent biotechnology companies in the world. If you would like more information, please contact us.
References
- Choudhary, S. and C. Schmidt-Dannert (2010). "Applications of quorum sensing in biotechnology." Applied microbiology and biotechnology. 86 (5).
- Fan, Q. et al. (2022). "Contribution of quorum sensing to virulence and antibiotic resistance in zoonotic bacteria." Biotechnology advances. 59.
- Haque, M. et al. (2020). "Quorum sensing: a new prospect for the management of antimicrobial-resistant infectious diseases." Expert review of anti-infective therapy.